Sepsis, a leading cause of death in the United States, is now viewed physiologically as a proinflammatory and procoagulant response to invading pathogens. There are three recognized stages in the… View full post on NEJM — Collection Updates for Critical Care

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Background: Recombinant human activated protein C was shown in the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study to reduce mortality among patients with severe sepsis…. View full post on NEJM — Collection Updates for Critical Care

American Heart Association Rapid Access Journal Report View full post on News releases (Heart News)

Platelet transfusions carry a serious risk of bacterial sepsis. Platelets are stored at room temperature for no longer than 120 hours (five days), and a single bacterium of the type… View full post on NEJM — Collection Updates for Critical Care

American Heart Association Rapid Access Journal Report View full post on News releases (Heart News)

Background: Some observational studies suggest that the use of pulmonary-artery catheters to guide therapy is associated with increased mortality.Methods: We performed a randomized trial comparing goal-directed therapy guided by a… View full post on NEJM — Collection Updates for Critical Care